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Partial Achilles tendon ruptures associated with fluoroquinolone antibiotics: a case report and literature review
W C McGarvey1, D Singh, S G Trevino
1Department of Orthopaedic Surgery, Baylor College of Medicine, Houston, Texas, USA.
Abstract:
Fluoroquinolone antibiotics (such as olprofloxacin, pefloxacin, ofloxacin, norfloxacin, temafloxacin, etc.) have recently been implicated in the etiology of Achilles tendinitis and subsequent tendon rupture. We report on a patient with bilateral partial Achilles tendon ruptures associated with ciprofloxacin therapy and present a review of the current literature on this increasingly recognized complication. Treatment with fluoroquinolones should be discontinued at the first sign of tendon inflammation so as to reduce the risk of subsequent rupture. Magnetic resonance imaging is useful in distinguishing between Achilles tendinitis and partial tendon rupture.
Insights
Fluoroquinolone antibiotics can cause Achilles tendinitis and rupture. Discontinue these drugs at the first sign of tendon inflammation to prevent severe tendon damage.
Area of Science:
- Pharmacology
- Orthopedic Surgery
- Radiology
Background:
- Fluoroquinolone antibiotics are associated with Achilles tendinitis and tendon rupture.
- This complication is increasingly recognized in clinical practice.
Observation:
- A patient experienced bilateral partial Achilles tendon ruptures while undergoing ciprofloxacin therapy.
- Literature review confirms fluoroquinolones as a potential cause of Achilles tendon issues.
Findings:
- Ciprofloxacin therapy was linked to bilateral partial Achilles tendon ruptures.
- Early discontinuation of fluoroquinolones can mitigate the risk of tendon rupture.
Implications:
- Clinicians should monitor patients for Achilles tendinitis during fluoroquinolone treatment.
- Magnetic resonance imaging aids in diagnosing tendinitis versus partial tendon rupture.
- Awareness of this adverse effect is crucial for patient safety and effective treatment.