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Ascariasis

M S Khuroo1

  • 1Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.

Gastroenterology Clinics of North America
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Ascariasis, a global roundworm infection, impacts billions, causing severe illness and death, particularly in children in developing nations. Effective drugs exist for mass treatment and control of this widespread parasitic disease.

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Area of Science:

  • Global Health
  • Infectious Diseases
  • Parasitology

Background:

  • Ascariasis is a widespread helminthic infection affecting over 1.4 billion people globally, predominantly in Asia and Latin America.
  • While many infections are asymptomatic, heavy worm loads cause significant morbidity, including stunted growth, cognitive impairment, and malnutrition in children.
  • Complications include intestinal obstruction, appendicitis, and biliary/pancreatic disease (HPA), especially in endemic areas.

Purpose of the Study:

  • To review the global distribution, clinical manifestations, and management of ascariasis.
  • To highlight the diagnostic utility of imaging and endoscopic procedures for complicated cases.
  • To discuss effective pharmacological interventions for disease control.

Main Methods:

Related Experiment Videos

  • Literature review of ascariasis epidemiology, clinical presentations, and treatment options.
  • Emphasis on diagnostic modalities such as ultrasonography and ERCP for biliary and pancreatic ascariasis.
  • Discussion of anthelmintic drugs for mass therapy and control.

    • Main Results:

    • Ascariasis is prevalent worldwide, with severe disease and mortality concentrated in endemic regions.
    • Complications like intestinal obstruction and hepatobiliary ascariasis (HPA) are significant concerns.
    • Ultrasonography and ERCP are valuable for diagnosing and managing complicated ascariasis.
    • Several anthelmintics (pyrantel pamoate, mebendazole, albendazole, levamisole) are effective for treatment and mass drug administration.

    Conclusions:

    • Ascariasis poses a substantial global health burden, necessitating effective control strategies.
    • Prompt diagnosis and management of complications are crucial for reducing morbidity and mortality.
    • Anthelmintic drugs provide effective means for controlling ascariasis in endemic populations.