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Combined dapsone and clofazimine intoxication

R M Hoetelmans¹, J M Otten, C H Koks

¹Department of Pharmacy, Slotervaart Hospital, Amsterdam, The Netherlands.

Human & Experimental Toxicology

|August 1, 1996

Summary

This summary is machine-generated.

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This case study details a man who overdosed on dapsone and clofazimine. Treatment with activated charcoal and sodium sulphate helped manage dapsone and clofazimine levels, while methylene blue treated dapsone-induced methaemoglobinaemia.

Area of Science:

Pharmacology
Clinical Toxicology
Internal Medicine

Background:

Combined dapsone and clofazimine intoxication is rare.
Understanding the pharmacokinetics of these drugs during overdose is crucial for effective treatment.

Observation:

A patient ingested a significant quantity of dapsone, clofazimine, and rifampicin.
Clinical presentation included dapsone-induced methaemoglobinaemia (48% at admission).

Findings:

Gastric lavage, activated charcoal, and sodium sulphate administration resulted in elimination half-lives of 11.1 h for dapsone and 10.8 h for monoacetyldapsone.
A rapid initial decrease in clofazimine plasma concentration was observed, followed by stabilization.
Methylene blue effectively treated the dapsone-induced methaemoglobinaemia.

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Implications:

This case highlights the importance of prompt and aggressive management of combined dapsone and clofazimine overdose.
Pharmacokinetic data from this event can inform future treatment strategies for similar intoxications.
Successful management underscores the efficacy of activated charcoal, sodium sulphate, and methylene blue in overdose scenarios.