Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endodermal sinus tumor in children

A M Davidoff1, A Hebra, N Bunin

  • 1Department of Surgery, Children's Hospital of Philadelphia, PA 19104, USA.

Journal of Pediatric Surgery
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of adjuvant chemotherapy after laparotomy for Wilms tumor and neuroblastoma.

Pediatric surgery international·2021
Same author

Outcomes of a pediatric surgical oncology fellowship in a pediatric cancer institution.

Pediatric blood & cancer·2017
Same author

Long-term outcomes of pediatric and adolescent mediastinal germ cell tumors: a single pediatric oncology institutional experience.

Pediatric surgery international·2016
Same author

Long-term functional outcomes and quality of life in adult survivors of childhood extremity sarcomas: a report from the St. Jude Lifetime Cohort Study.

Journal of cancer survivorship : research and practice·2016
Same author

Guidewire Catheter Exchange in Pediatric Oncology: Indications, Postoperative Complications, and Outcomes.

Pediatric blood & cancer·2016
Same author

Risk factors and timing of relapse after allogeneic transplantation in pediatric ALL: for whom and when should interventions be tested?

Bone marrow transplantation·2015
Same journal

Reimagining the Surgical Safety Checklist Through a Pediatric Lens.

Journal of pediatric surgery·2026
Same journal

Bridge Fixation Provides Consistent Implant Stability Across Surgical Techniques: A Multicenter Study.

Journal of pediatric surgery·2026
Same journal

National Benchmarks for Penetrating Head Injury in U.S. Children and Adolescents: Mechanism, Intent, and Disparities in Mortality.

Journal of pediatric surgery·2026
Same journal

Long-Term Growth and Neurodevelopmental Outcomes of a Standardized Gastroschisis Feeding Protocol: a retrospective cohort study.

Journal of pediatric surgery·2026
Same journal

Economic Evaluation of Hirschsprung Disease Testing Strategies for Children with Medically-Refractory Chronic Constipation: A Cost-Effectiveness Analysis.

Journal of pediatric surgery·2026
Same journal

Preoperative underweight is associated with a more complicated perioperative course and impairs recovery in Hirschsprung's disease: The pivotal role of weight-for-age z-score.

Journal of pediatric surgery·2026
See all related articles

Endodermal sinus tumors (EST) in children are rare but treatable. Improved survival rates are linked to modern chemotherapy and alpha-fetoprotein (AFP) monitoring, especially for testicular tumors.

Area of Science:

  • Pediatric Oncology
  • Pediatric Surgery
  • Medical Oncology

Background:

  • Malignant germ cell tumors represent approximately 3% of pediatric neoplasms.
  • Endodermal sinus tumor (EST) is the most frequent histological subtype in children.
  • EST can arise from various primary sites, including sacrococcygeal, testicular, and ovarian locations.

Purpose of the Study:

  • To review the 22-year institutional experience in managing pediatric endodermal sinus tumors.
  • To evaluate treatment outcomes and identify prognostic factors.
  • To assess the role of surveillance methods like alpha-fetoprotein (AFP) and imaging in recurrence detection.

Main Methods:

  • Retrospective review of 37 pediatric patients with endodermal sinus tumors managed over 22 years.

Related Experiment Videos

  • Analysis of primary tumor site, metastatic disease at presentation, treatment regimens, and outcomes.
  • Correlation of serum alpha-fetoprotein (AFP) levels and computed tomography (CT) findings with recurrence and survival.

    • Main Results:

    • The overall 2-year survival rate was 70%, a significant improvement over historical data.
    • Testicular primary tumors had a 100% survival rate, while ovarian and sacrococcygeal primaries had 67% and 60% survival, respectively.
    • Serum AFP was a highly sensitive marker for surveillance, detecting recurrence earlier than CT scans; second-look operations were reserved for elevated AFP levels.

    Conclusions:

    • Prognosis for pediatric endodermal sinus tumors has improved, likely due to cisplatin-based chemotherapy and sensitive AFP surveillance.
    • AFP monitoring is crucial for early detection of relapse, guiding treatment decisions.
    • Treatment strategies and surveillance protocols have significantly impacted survival rates in pediatric EST.