Antithrombotic and fibrinolytic factors. A review

Excessive or nonphysiologic thrombogenesis and fibrinolysis accompanies many diseases. Several specific proteins involved in the physiologic regulation and maintenance of blood in a fluid state are reviewed in this article. Assays for these proteins or evidence of their function (antithrombin III, protein C, protein S, plasminogen/plasmin, tissue plasminogen activator, plasminogen activator inhibitor I, fibrinogen/fibrin degradation products, and thrombin/antithrombin complexes) are described. Principles, general methodology, and application in veterinary medicine are discussed. Although most of the investigative work and knowledge concerning these proteins and assays has been in human beings, their use and application in veterinary medicine is becoming more available in research laboratories at referral centers and some larger commercial veterinary laboratories. Use and interpretation of these assays will help clinicians and researchers better understand pathophysiologic processes occurring in various diseases associated with thrombogenesis and excessive fibrinolysis.