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Updated: Aug 10, 2026

Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
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The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus
H Schellekens1, H Niphuis, L Buijs
1Diagnostic Centre SSDZ, Department of Infectious Diseases and Immunology, The Netherlands.
Abstract:
The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-gamma B,D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.
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