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(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties
T C McMorris1, M J Kelner, W Wang
1Department of Chemistry, University of California at San Diego, La Jolla, 92093-0506, USA.
Journal of Natural Products
|September 1, 1996
Abstract:
Reaction of the fungal sesquiterpene illudin S with excess paraformaldehyde in dilute H2SO4 gives (hydroxymethyl)acylfulvene. The primary allylic hydroxyl thus formed can undergo very facile replacement by a variety of nucleophiles. (Hydroxymethyl)acylfulvene (MGI.114) was more toxic than a precursor, acylfulvene, but less toxic than the parent compound illudin S to HL 60 cells.