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Mycosis fungoides with marked hyperpigmentation

A Kikuchi1, H Shimizu, T Nishikawa

  • 1Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

Dermatology (Basel, Switzerland)
|January 1, 1996
PubMed
Summary

This study reports a rare case of mycosis fungoides presenting as hyperpigmented skin lesions in a Japanese male. The findings highlight unusual pigmentary changes in this condition, particularly in non-white individuals.

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Area of Science:

  • Dermatology
  • Oncology

Background:

  • Pigmentary changes are common in mycosis fungoides, with hypopigmentation and poikiloderma frequently reported.
  • Hyperpigmented lesions are less common presentations of mycosis fungoides in the medical literature.

Observation:

  • A 57-year-old Japanese male presented with mycosis fungoides manifesting as marked hyperpigmentation.
  • Initial lesions were itchy, annular erythema with central pigmentation on extremities, evolving over 5 years.
  • Lesions enlarged, became elevated, and showed significant hyperpigmentation.

Findings:

  • Histopathology confirmed mycosis fungoides with elongated rete ridges and atypical lymphoid cells.
  • Numerous melanin granules were observed in epidermal melanocytes and dermal melanophages.
  • The case demonstrates a rare presentation of mycosis fungoides with pronounced hyperpigmentation.

Implications:

  • This case expands the understanding of clinical presentations of mycosis fungoides.
  • It underscores the importance of considering hyperpigmentation as a potential sign, especially in non-white patients.
  • Further research into the mechanisms of hyperpigmentation in mycosis fungoides is warranted.

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