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Effect of corticosterone on serotonin and catecholamine receptors and uptake sites in rat frontal cortex
J W Crayton1, I Joshi, A Gulati
1Biological Psychiatry Laboratories (116A7), Hines VA Hospital, IL 60141, USA.
Brain Research
|July 29, 1996
Abstract:
The effects of corticosterone (1 mg/kg per day for 7 days) on serotonin 5-HT1A, 5-HT2A, 5-HT uptake sites, and alpha 2-adrenergic receptor sites were measured. Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively). No significant differences were found in other measures. It is possible that corticosteroids exert some of their behavioral effects via regulation of 5-HT1A sites in frontal cortex.