Interrelation between two anticomplement cobra venom factors isolated from crude Naja naja cobra venom

Two moieties occurring in crude Naja naja cobra venom were found to possess anticomplement activity. Both materials possessed similar molecular weights and specific activities but dissimilar elution profiles upon ion-exchange chromatography. The anticomplement activities of these materials were maintained upon digestion with neuraminidase, and their elution profiles from cation-exchange chromatography became identical after this treatment. It was concluded that the differences between the two anticomplement materials were due to their different sialic acid contents.