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Related Experiment Videos

Rectal absorption of nitrofurantoin

E L Parrott, L E Matheson

    Journal of Pharmaceutical Sciences
    |July 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Nitrofurantoin rectal absorption was poorer than oral, but specific suppository bases achieved adequate urinary levels. This offers an alternative route for patients experiencing gastric upset with oral nitrofurantoin.

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    Area of Science:

    • Pharmacology
    • Drug Delivery Systems
    • Urology

    Background:

    • Nitrofurantoin is a common antibiotic for urinary tract infections.
    • Oral administration can cause gastrointestinal upset in some patients.
    • Rectal administration offers a potential alternative route.

    Purpose of the Study:

    • To evaluate nitrofurantoin adsorption from various suppository bases in humans.
    • To compare rectal absorption with gastrointestinal absorption.
    • To identify suitable rectal formulations for achieving adequate therapeutic concentrations.

    Main Methods:

    • Studied adsorption of nitrofurantoin from seven different suppository bases.
    • Utilized urinary excretion measurements to assess drug absorption.

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  • Administered 400 mg of nitrofurantoin rectally.

    • Main Results:

    • Rectal absorption of nitrofurantoin was generally poorer than gastrointestinal absorption.
    • Polyethylene glycol-polysorbate 80 and polyethylene glycol-silica bases yielded adequate urinary nitrofurantoin concentrations.
    • These bases facilitated sufficient drug levels for potential therapeutic efficacy.

    Conclusions:

    • Nitrofurantoin can be effectively administered rectally using specific suppository bases.
    • This route provides an alternative for patients intolerant to oral nitrofurantoin due to gastric side effects.
    • Rectal nitrofurantoin therapy is a viable option for managing urinary tract infections in specific patient populations.