Haemodynamic and other effects of sulphonylurea drugs on the heart

Antidiabetic sulphonylureas have attracted a great deal of interest in experimental cardiology to evaluate the role of ATP-sensitive potassium channels in the cardiovascular system. It is well established that KATP channels are present in cardiac cells and also in vascular smooth muscle cells and are implicated in the regulation of myocardial and vascular function. It follows that drugs which open, or inhibit the opening of these channels, might profoundly modify cardiovascular function both under physiological and pathophysiological conditions. This paper reviews the evidence for the role of KATP channels in the cardiovascular system and discusses how the different generations of sulphonylurea drugs interfere with cardiac function. We will particularly concentrate on the haemodynamic effects of different sulphonylureas and shortly discuss how these drugs modify ischaemia-reperfusion arrhythmias.