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Prophylactic effect of serotonin uptake inhibitors against motion sickness in Suncus murinus
1Department of Chemical Pharmacology, Faculty of Pharmaceutical Science, University of Tokyo, Japan.
European Journal of Pharmacology
|August 1, 1996
Abstract:
The prophylactic effect of serotonin uptake inhibitors, imipramine and fluoxetine, against motion sickness was investigated in Suncus murinus. Imipramine (s.c.) and fluoxetine (i.p.) inhibited motion-induced emesis dose dependently with ID50 values of 1.7 and 26 mg/kg, respectively. The results suggest that increasing the concentration of serotonin in the synaptic cleft can prevent motion-induced emesis and that serotonin uptake inhibitors are effective as anti-motion sickness drugs.