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Cavernous sinus syndrome in Hodgkin's disease
S E Kasner1, S L Galetta, D J Vaughn
1Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Summary
Hodgkin's disease rarely causes isolated cavernous sinus syndrome, unlike non-Hodgkin's lymphoma. This study reports two Hodgkin's disease cases with cavernous sinus recurrence preceding systemic disease.
Area of Science:
- Neurology
- Oncology
- Ophthalmology
Background:
- Cavernous sinus syndrome (CSS) is typically associated with non-Hodgkin's lymphoma.
- Isolated CSS from Hodgkin's disease (HD) has not been previously reported.
Observation:
- This study reviews 16 cases of CSS due to non-Hodgkin's lymphoma.
- Two patients with Hodgkin's disease in remission developed recurrent disease presenting as isolated cavernous sinus syndrome.
- Magnetic Resonance Imaging (MRI) confirmed mass lesions in the cavernous sinus for both patients.
Findings:
- Recurrence of Hodgkin's disease in the cavernous sinus can occur in patients in clinical remission.
- Cavernous sinus recurrence may precede detectable systemic recurrence of Hodgkin's disease.
- Corticosteroids and radiation therapy provided palliative benefits.
Implications:
- Highlights a rare presentation of Hodgkin's disease recurrence.
- Suggests considering Hodgkin's disease in the differential diagnosis of isolated cavernous sinus syndrome.
- Emphasizes the importance of vigilant monitoring for localized recurrence in treated Hodgkin's disease patients.