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Immunostimulating polysaccharides from Panax notoginseng

H Gao1, F Wang, E J Lien

  • 1Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, LA 90033, USA.

Pharmaceutical Research
|August 1, 1996
PubMed
Summary

Polysaccharides from Panax notoginseng demonstrate immunostimulating effects in vitro. These compounds show potential as novel immunostimulants for preventing and treating immune-related diseases.

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Area of Science:

  • Immunology
  • Natural Products Chemistry

Background:

  • Panax notoginseng (P. notoginseng) is a traditional medicinal herb.
  • Its polysaccharides are known for various biological activities.
  • Further investigation into their immunomodulatory effects is warranted.

Purpose of the Study:

  • To isolate and characterize polysaccharides from P. notoginseng.
  • To evaluate their in vitro effects on the immune system.
  • To identify potential immunostimulants for disease prevention and treatment.

Main Methods:

  • Polysaccharides were extracted and purified using aqueous solution and column chromatography.
  • Anticomplementary activity was assessed using human serum and sheep red blood cells.
  • Interferon-gamma and tumor necrosis factor inductive activities were studied in mouse lymphocytes and macrophages.

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Main Results:

  • Four homogeneous polysaccharides (PF3111, PF3112, PBGA11, PBGA12) were prepared, with molecular weights from 37 kD to 760 kD.
  • These heteroglycans contain glucose, galactose, arabinose, mannose, and xylose.
  • PBGA12 exhibited significant anticomplementary activity; all polysaccharides induced interferon-gamma and tumor necrosis factor production.

Conclusions:

  • P. notoginseng polysaccharides possess significant in vitro immunostimulating properties.
  • These findings support their potential use as natural immunostimulants.