Related Experiment Video
Updated: Feb 14, 2026
08:37
Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
Published on: July 3, 2025
850
Primary sclerosing cholangitis and liver transplantation
I J Klompmaker1, E B Haagsma, R Verwer
1Dept. of Hepato-Gastroenterology, University Hospital, Groningen, The Netherlands.
Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1996
Summary
Liver transplantation outcomes for primary sclerosing cholangitis (PSC) have improved over time. While initially showing lower survival rates, current data suggest better prognoses, especially with updated surgical approaches.
Area of Science:
- Hepatology
- Gastroenterology
- Transplant Surgery
Background:
- Primary sclerosing cholangitis (PSC) is a chronic liver disease.
- PSC is strongly associated with ulcerative colitis and cholangiocarcinoma.
- Liver transplantation is a treatment option for end-stage PSC.
Purpose of the Study:
- To review the literature on liver transplant outcomes for PSC.
- To present the results from the Groningen transplant center for PSC liver transplantation.
Main Methods:
- Literature review of studies reporting liver transplantation for PSC.
- Analysis of outcomes data from the Groningen transplant center.
Main Results:
- Initial reports indicated lower survival rates for PSC liver transplants compared to other indications.
- Improved survival rates are observed in later reports, potentially due to avoiding certain surgical interventions.
- Ulcerative colitis does not negatively impact liver transplant outcomes, but colon cancer screening may be needed.
Conclusions:
- Liver transplant outcomes for PSC have improved over time.
- Modern surgical techniques have likely contributed to better prognoses.
- Further research and monitoring, particularly for associated conditions, are warranted.
Related Concept Videos
01:27Liver Histology
4.5K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
Hepatocytes perform a variety of essential functions. They secrete...
4.5K
01:30Liver Physiology
3.8K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.8K
01:24Liver Regeneration
4.4K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.4K
01:17Gross Anatomy of the Liver
2.1K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.1K
01:47Primary Active Transport
201.0K
In contrast to passive transport, active transport involves a substance being moved through membranes in a direction against its concentration or electrochemical gradient. There are two types of active transport: primary active transport and secondary active transport. Primary active transport utilizes chemical energy from ATP to drive protein pumps that are embedded in the cell membrane. With energy from ATP, the pumps transport ions against their electrochemical gradients—a direction...
201.0K
01:26Diseases of the Liver and Gallbladder
2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K