Helicobacter pylori and gastric carcinogenesis

Helicobacter pylori causes chronic persistent gastritis in virtually all infected subjects, leading to development of atrophic gastritis, intestinal metaplasia and eventually dysplasia and gastric cancer in a number of infected subjects. Based on the available evidence, an IARC monograph committee classified H. pylori as a class I carcinogen to humans. Prospective studies suggest that infection increases the risk for atrophic gastritis and gastric cancer at least 8-fold. In the presence of infection, the risk for atrophy and cancer seems higher if a subject becomes infected in early childhood, if infection occurs with a cagA positive strain, and if acid output is decreased.

H.pylori is a gastric carcinogen. The clinical implications and possible strategies for cancer prevention have to be delineated in the near future.