Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interleukins in acute pancreatitis

J Schölmerich1

  • 1Dept. of Internal Medicine I, University of Regensburg, Germany.

Scandinavian Journal of Gastroenterology. Supplement
|January 1, 1996
PubMed
Summary

Cytokines and antagonists are released during acute pancreatitis, potentially predicting disease severity. Anticytokine therapies and plasmapheresis warrant further investigation for treating severe pancreatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of variables influencing resistin serum levels in patients with type 1 and type 2 diabetes mellitus.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2004
Same author

Treatment of active psoriatic arthritis with the PPARgamma ligand pioglitazone: an open-label pilot study.

Rheumatology (Oxford, England)·2004
Same author

Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease.

Inflammatory bowel diseases·2004
Same author

[Diagnosis and therapy of ulcerative colitis: results of an evidence based consensus conference by the German society of Digestive and Metabolic Diseases and the competence network on inflammatory bowel disease].

Zeitschrift fur Gastroenterologie·2004
Same author

[Ulcerative colitis. Chronic active course].

Zeitschrift fur Gastroenterologie·2004
Same author

[33-year old patient with thoraco-abdominal pain and differences of blood pressure].

Der Internist·2004

Area of Science:

  • Immunology
  • Gastroenterology
  • Critical Care Medicine

Background:

  • Inflammatory cells release cytokines and antagonists during acute pancreatitis, especially severe forms.
  • These mediators are detectable early in disease progression, as evidenced in animal and human pancreatitis models (e.g., post-ERCP).

Purpose of the Study:

  • To explore the role of cytokines and their antagonists in acute pancreatitis.
  • To assess the predictive value of cytokine measurements for disease course.
  • To evaluate the potential of anticytokine strategies and plasmapheresis in managing severe acute pancreatitis.

Main Methods:

  • Analysis of cytokine and antagonist levels in acute pancreatitis.
  • Comparison of cytokine measurements with simpler clinical parameters (e.g., clinical judgment, leucocyte elastase).
  • Review of experimental data on anticytokine therapies and plasmapheresis effects on cytokine patterns.

Main Results:

  • Cytokine and antagonist release is characteristic of acute pancreatitis, particularly severe cases.
  • Cytokine measurements can predict disease progression, though simpler parameters may suffice.
  • Experimental studies suggest potential benefits from anticytokine strategies (e.g., IL-10, soluble TNFα-receptors) and plasmapheresis.

Conclusions:

  • Cytokines and their antagonists are key players in acute pancreatitis pathogenesis and progression.
  • While cytokine monitoring aids prediction, simpler clinical tools are also effective.
  • Further clinical trials are needed to validate anticytokine therapies and plasmapheresis for severe acute pancreatitis.

Related Experiment Videos