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Electrolytic Inferior Vena Cava Model (EIM) of Venous Thrombosis
Published on: July 12, 2011
Deep venous thrombosis and lupus anticoagulant. A case-control study
P Simioni1, P Prandoni, E Zanon
1Institute of Medical Semeiotics, University Hospital of Padua, Italy.
Thrombosis and Haemostasis
|August 1, 1996
Summary
Lupus anticoagulant (LA) is significantly linked to deep-vein thrombosis (DVT) in patients without systemic lupus erythematosus. This study found LA in 8.5% of DVT patients, suggesting a strong association.
Area of Science:
- Hematology
- Vascular Medicine
- Immunology
Background:
- Evidence linking deep-vein thrombosis (DVT) with lupus anticoagulant (LA) in patients without systemic lupus erythematosus is limited.
- Investigating this association is crucial for understanding thrombotic risks.
Purpose of the Study:
- To determine the association between lupus anticoagulant (LA) and deep-vein thrombosis (DVT) in patients presenting with clinically suspected lower limb DVT.
- To quantify the risk of DVT in the presence of LA.
Main Methods:
- A case-control study involving 176 outpatients with suspected DVT.
- Lupus anticoagulant (LA) levels were measured.
- Association quantified using odds ratios (OR).
Main Results:
- Deep-vein thrombosis (DVT) was confirmed in 33.5% of patients.
- Lupus anticoagulant (LA) was detected in 8.5% of patients with DVT, compared to 0% in those without DVT (P=0.007).
- The odds ratio for acute DVT in patients with LA was 10.7 (95% CI: 1.2-94.2).
Conclusions:
- Lupus anticoagulant (LA) is significantly associated with deep-vein thrombosis (DVT) in symptomatic individuals.
- Further research is required to elucidate the clinical significance of this association.
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