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[Myoglobinuria following anesthesia with enflurane and succinylcholine in an asthmatic child on theophylline]
1Department of Anesthesiology, Fukuoka University, School of Medicine.
Insights
An asthmatic child on theophylline experienced muscle rigidity and myoglobinuria after enflurane anesthesia and succinylcholine. This case highlights potential interactions between theophylline, anesthetics, and muscle complications.
Area of Science:
- Anesthesiology
- Pharmacology
- Pediatric Medicine
Background:
- Theophylline, a xanthine derivative, is used for asthma management.
- Inhalation anesthetics like enflurane are common in pediatric anesthesia.
- Succinylcholine is a depolarizing neuromuscular blocker used to facilitate intubation.
Abstract:
An 8-year-old asthmatic child on theophylline was anesthetized with enflurane in nitrous oxide and oxygen. He developed a generalized muscle rigidity after intravenous succinylcholine. Although the maximum rectal temperature was 37.9 degrees C, a marked elevation in muscle-derived enzymes and myoglobinuria were observed. The relations among theophylline which is a derivative of xanthines, inhalation anesthetics, and myoglobinuria are discussed.