Related Experiment Video
Updated: Aug 13, 2026

Behavioral Approaches to Studying Innate Stress in Zebrafish
Published on: May 1, 2019
Efficacy of buspirone in alcohol dependence: a review
T S Malec1, E A Malec, M Dongier
1Douglas Hospital Research Center, Alcohol Research Program, Montreal, Quebec, Canada.
Abstract:
The five published controlled studies on the effects of buspirone in alcoholism treatment are reviewed. They have been conducted mostly in alcoholics with comorbid anxiety. Significant differences in favor of the medication were observed in several psychopathological measures (anxiety, depression, hostility, interpersonal sensitivity, and global psychopathology). In only two studies were alcohol craving and consumption found influenced. Metaanalysis showed positive effects of buspirone on treatment retention, as well as on anxiety. It can be concluded that the main effect of buspirone in the treatment of alcoholism is not on ethanol consumption per se, but on associated psychopathological symptoms. A favorable safety profile and a lack of interaction with alcohol make buspirone a useful pharmacological adjunct in the treatment of alcoholism.
More Related Videos
Related Concept Videos
CNS Depressants: Alcohol and Nicotine
CNS Depressants: Barbiturates and Benzodiazepines
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
Anxiolytic Drugs: Benzodiazepines and Buspirone
Depressants
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...

