Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Membrane permeability equations and their solutions for red cells

J H Milgram, A K Solomon

    The Journal of Membrane Biology
    |June 6, 1977
    PubMed
    Summary

    This study refines mathematical models for nonelectrolyte transport across cell membranes, improving accuracy by accounting for cell volume changes. New methods offer more precise solutions than commonly used approximations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Characterization of biological membranes by equivalent pores.

    The Journal of general physiology·2009
    Same author

    Tracer diffusion and unidirectional fluxes.

    Biophysical journal·2009
    Same author

    Abnormal erythrocyte anion exchange in Alzheimer disease.

    Archives of pathology & laboratory medicine·2000
    Same author

    Kinetics of chloride-bicarbonate exchange across the human red blood cell membrane.

    The Journal of membrane biology·1997
    Same author

    Permeability and reflection coefficients of urea and small amides in the human red cell.

    The Journal of membrane biology·1996
    Same author

    Inhibition of red cell urea flux by anion exchange inhibitors.

    Biochimica et biophysica acta·1994

    Area of Science:

    • Biophysics
    • Cell Biology
    • Mathematical Modeling

    Background:

    • Existing mathematical models for nonelectrolyte transport across cell membranes often rely on significant approximations.
    • Accurate modeling is crucial for understanding cellular processes and drug delivery.

    Purpose of the Study:

    • To critically examine and improve mathematical equations for nonelectrolyte transport across cell membranes.
    • To develop more accurate solutions by minimizing approximations and incorporating cell volume variations.

    Main Methods:

    • Developed new mathematical formulations for nonelectrolyte transport, specifically including the effects of varying hemoglobin concentration and cell volume changes in red blood cells.
    • Investigated two novel methods for solving these refined equations, providing sample calculations.
    • Compared results with commonly used linearized equations.

    Main Results:

    • The refined equations accurately account for variations in apparent nonosmotic water and solute volume within the cell.
    • The developed solution methods avoid inaccuracies inherent in previously published linearized equations.
    • Sample calculations demonstrate the practical application and improved precision of the new methods.

    Conclusions:

    • The study presents more accurate mathematical models for nonelectrolyte transport across cell membranes.
    • Accounting for cell swelling/shrinking and associated water/solute volume changes is critical for precise modeling.
    • The novel solution methods offer a significant improvement over existing approaches for certain applications.

    Related Experiment Videos