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Related Experiment Videos

Aging and the kidney

M Epstein1

  • 1Nephrology Section, Department of Veterans Affairs Medical Center, Miami, Florida 33125, USA.

Journal of the American Society of Nephrology : JASN
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Aging causes fewer renal changes than previously believed, with reduced renal reserve being a key issue. These age-related kidney function changes become significant during acute illness or with comorbid conditions.

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Area of Science:

  • Nephrology
  • Gerontology
  • Physiology

Background:

  • Advancing age is associated with numerous changes in renal structure and function.
  • Previous assessments were limited by cross-sectional designs and institutionalized elderly subjects.
  • Methodological considerations in population selection can confound aging effect assessments.

Purpose of the Study:

  • To reappraise the effects of aging on renal structure and function.
  • To clarify the extent of age-related changes in kidney function.
  • To understand the clinical significance of these changes.

Main Methods:

  • Utilized recent longitudinal studies with appropriate patient cohorts.
  • Included potential kidney transplant donors without pre-existing renal disease.

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  • Focused on methodologic considerations to avoid confounding factors.

    • Main Results:

    • Morphological and functional changes of aging are less pronounced than previously thought.
    • A key finding is a diminished renal reserve.
    • The kidney's ability to respond to challenges (excesses or deficits) is constrained.

    Conclusions:

    • Age-related renal alterations are generally minor under normal conditions.
    • Clinical significance arises when residual renal function is challenged by acute illness.
    • Comorbid conditions like hypertension and heart disease can amplify age-related renal abnormalities.