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Relative bioavailability of microgranulated sulfadimidine in veal calves

P Anfossi1, C Montesissa, P Pezzi

  • 1Department of Public Veterinary Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Ozzano Emilia (BO), Italy.

Journal of Veterinary Pharmacology and Therapeutics
|August 1, 1996
PubMed

Insights

Microgranulated sulfadimidine shows poor bioavailability in milk-fed calves due to rapid gastrointestinal transit. This formulation is unsuitable for calves, though it may be effective in species with slower digestion.

Area of Science:

  • Veterinary pharmacology
  • Animal science

Background:

  • Sulfadimidine is a commonly used sulfonamide antibiotic in veterinary medicine.
  • Formulation affects drug absorption and bioavailability.

Purpose of the Study:

  • To compare the pharmacokinetics of free and microgranulated sulfadimidine in milk-fed calves.
  • To evaluate the suitability of microgranulated sulfadimidine for this animal model.

Main Methods:

  • Oral administration of sulfadimidine (180 mg/kg) in a crossover study design.
  • Comparison of plasma concentration-time profiles, including Area Under the Curve (AUC) and maximum plasma concentration (Cmax).

Main Results:

  • Microgranulation significantly delayed sulfadimidine absorption and reduced bioavailability.
  • AUC(0-infinity) decreased from 7400 to 3781 micrograms.h/mL.
  • Cmax reduced from 188.1 +/- 39.0 to 84.41 +/- 22.6 micrograms/mL.

Conclusions:

  • Microgranulated sulfadimidine is not suitable for milk-fed calves due to rapid gastrointestinal transit limiting drug release and bioavailability.
  • This formulation might be more effective in animal species with slower gastrointestinal transit times.

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