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Related Experiment Videos

Pharmacokinetic interaction between diltiazem and nortriptyline

S Krähenbühl1, V Smith-Gamble, C L Hoppel

  • 1Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, USA.

European Journal of Clinical Pharmacology
|January 1, 1996
PubMed
Summary

Concomitant administration of diltiazem significantly increases plasma concentrations of nortriptyline. This pharmacokinetic interaction likely stems from diltiazem reducing the first-pass clearance of nortriptyline, enhancing its bioavailability.

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Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Drug Interactions

Background:

  • Nortriptyline is a tricyclic antidepressant.
  • Diltiazem is a calcium channel blocker used for hypertension and angina.
  • Potential for drug interactions exists between medications metabolized by similar pathways.