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Related Experiment Videos

Cerebrospinal fluid values in the term neonate

A Ahmed1, S M Hickey, S Ehrett

  • 1Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA.

The Pediatric Infectious Disease Journal
|April 1, 1996
PubMed
Summary

Cerebrospinal fluid (CSF) white blood cell counts in healthy newborns are established using strict criteria. These new reference values aid in evaluating neonates with suspected infections.

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Area of Science:

  • Neonatal Medicine
  • Pediatric Neurology
  • Clinical Chemistry

Background:

  • Cerebrospinal fluid (CSF) values in noninfected neonates are not well-established.
  • Previous studies lack consistent criteria for defining the noninfected population.
  • This study aimed to define CSF values in neonates with rigorously excluded infection.

Purpose of the Study:

  • To establish reference ranges for cerebrospinal fluid (CSF) values in neonates within the first 30 days of life.
  • To improve the definition of the noninfected neonatal population using stringent inclusion criteria.
  • To assess age-related variability in CSF values during the neonatal period.

Main Methods:

  • Selection of neonates from aseptic meningitis studies.
  • Inclusion criteria: atraumatic lumbar puncture, no prior antibiotics, sterile cultures (blood, CSF, urine).

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  • Exclusion of viral disease using negative CSF viral culture and enterovirus PCR.

    • Main Results:

    • Mean CSF white blood cell (WBC) count in 108 noninfected neonates was 7.3 ± 14/mm³ (median 4/mm³).
    • Established 95% confidence interval for mean CSF WBC count (6.6–8.0/mm³).
    • No significant differences in mean CSF WBC counts were observed across different neonatal age categories.

    Conclusions:

    • Stringent criteria and PCR testing provide a more accurate representation of noninfected neonates.
    • The established CSF values serve as a reliable reference for evaluating febrile or ill neonates.
    • These findings enhance diagnostic capabilities for neonatal infections.