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Updated: Sep 12, 2026
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Pupillary response to topical tropicamide as a marker for Alzheimer's disease
A J Treloar1, M Assin, A J Macdonald
1Division of Psychiatry, United Medical and Dental Schools (Guy's), Bexley Hospital, Kent, UK.
Abstract:
The mydriatic response to eyedrops of the anticholinergic drug tropicamide at very low concentration (0.01%) was studied in subjects with Alzheimer's disease (AD, n = 10) and multi-infarct dementia (MID, n = 10). There was no significant difference in pupillary response between the two groups. The test is unlikely to be useful in differentiating different types of dementia.
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