Related Experiment Video

Updated: Oct 2, 2026

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine
10:05

Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine

Published on: July 7, 2016

[Differentiated treatment and prevention of arrhythmias in myocardial infarct]

V S Gasilin, A I Romanov, I I Bykov

    Kardiologiia
    |April 1, 1977
    PubMed

    Insights

    Preventive antiarrhythmic treatment reduces arrhythmias in myocardial infarction patients. Combining specific drugs with supportive therapies restored normal sinus rhythm in 85% of cases, improving patient outcomes.

    Area of Science:

    • Cardiology
    • Internal Medicine

    Background:

    • Myocardial infarction frequently leads to arrhythmias.
    • Arrhythmias pose a significant risk during acute and subacute phases.

    Purpose of the Study:

    • To evaluate the efficacy of preventive antiarrhythmic therapy in myocardial infarction patients.
    • To identify effective antiarrhythmic drugs and supportive treatments for various arrhythmia types.

    Main Methods:

    • Electrocardiographic monitoring of 900 patients during myocardial infarction.
    • Assessment of individual and combined antiarrhythmic drug efficacy.
    • Evaluation of supportive therapies including electrolytes and vitamins.

    Main Results:

    • Arrhythmias developed in 85% of patients without preventive therapy, versus 75.5% with it.
    • Supraventricular arrhythmias responded best to Chinidin, Inderal, and Hiluritmal.
    • Ventricular arrhythmias were effectively treated with Lidocaine, Chinidin, Novocainamide, Inderal, and Hiluritmal.
    • Combined drug therapy with supportive agents restored normal sinus rhythm in 85% of cases.
    • Electroimpulse therapy and cardiostimulation were used for refractory ventricular fibrillation and atrioventricular blocks, respectively.

    Conclusions:

    • Preventive antiarrhythmic treatment is crucial in managing myocardial infarction complications.
    • A combination of specific antiarrhythmic drugs and supportive therapies significantly improves rhythm restoration.
    • Tailored therapeutic strategies are necessary for different types of arrhythmias post-myocardial infarction.

    More Related Videos

    Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction06:57

    Ablation of Ischemic Ventricular Tachycardia Using a Multipolar Catheter and 3-dimensional Mapping System for High-density Electro-anatomical Reconstruction

    Published on: January 31, 2019

    Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy07:40

    Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy

    Published on: May 26, 2023

    Related Concept Videos

    Disturbances in Heart Rhythm01:29

    Disturbances in Heart Rhythm

    Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
    Arrhythmias are categorized by their speed, rhythm, and origin. A slow heart...
    Myocarditis III: Medical Management01:14

    Myocarditis III: Medical Management

    Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
    Acute Coronary Syndrome IV: Interprofessional Care01:28

    Acute Coronary Syndrome IV: Interprofessional Care

    IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
    Dysrhythmias VI: Management of Dysrhythmias01:25

    Dysrhythmias VI: Management of Dysrhythmias

    Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    Cardiomyopathy V: Interprofessional Care01:29

    Cardiomyopathy V: Interprofessional Care

    Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...