Methazid-induced vitamin B2 deficiency in rats and its prevention

It has been estimated that ten-day rectal administration of metazid in the form of suppositories (20 mg per 100 g of body mass) gives rise to vitamin B2 deficiency both in rats with initial vitamin B2 insufficiency and in those adequately supplied. This is confirmed by a decrease in the vitamin B2 content both in the liver and in the blood plasma. Development and use of suppositories containing combined preparation of metazid and riboflavin (in the dose of 100 micrograms per a rat according to the daily recommended allowance) completely prevent metazid-induced vitamin B2 deficiency.