[Types of hyperlipoproteinemia and thrombocyte survival in ischemic heart disease]

The life-span of methionie-Se75-labelled thrombocytes was studied in 46 patients with ischaemic heart disease and in 5 control individuals. In ischaemic heart disease patients the platelets life-span comprised 6.6+/-0.14 days, this period being smaller in patients over 60 years of age and in males, in contrast to younger patients and females. The presence of arterial hypertension and excessive body weight did not affect the life-span of the thrombocytes. Smoking, hypercholesterolemia and hypertriglyceridemia caused a statistically significant reduction of the circulation time of labelled thrombocytes. In patients with frequent attacks of angina pectoris and with postinfarction cardiosclerosis the life time of the platelets was shorter then in patients with painless forms of the disease and in those free of myocardial infarction. In Type II hyperlipoproteidemia the circulation period of labelled platelets comprised 6.3+/-0.16 days; in Type IV -- 6.7+/-0.29 days and in normolipemia -- 7.4+/-0.30 days. A distinct inverse correlation was established between the blood plasma cholesterol and thriglycerids level and the thrombocytes life-span. It was concluded that the reduction of the life-span of thrombocytes is attributed to the consumption of platelets by the processes of atherogenesis and chronic intravascular thrombus formation.