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Rheumatic manifestations of malignancy
J A Aviña-Zubieta1, H L Enkerlin, G Galindo-Rodriguez
1Rheumatic Disease Unit, Hospital de Especialidades Centro Medico La Raza, Mexico City, Mexico.
Current Opinion in Rheumatology
|January 1, 1996
Summary
Malignancy can present with diverse rheumatic symptoms, including arthritis and polymyositis. Recognizing these connections is crucial for effective cancer diagnosis and treatment.
Area of Science:
- Rheumatology
- Oncology
- Immunopathology
Background:
- Rheumatic diseases can manifest as a paraneoplastic syndrome in cancer patients.
- These manifestations pose diagnostic and therapeutic challenges for clinicians.
- Understanding the link between rheumatic conditions and malignancy is vital.
Purpose of the Study:
- To review the associations between rheumatic diseases and malignancy.
- To discuss recent literature on these associations.
- To highlight the importance of considering cancer in patients with rheumatic symptoms.
Main Methods:
- Literature review of articles published in the past year.
- Discussion of various rheumatic manifestations associated with neoplasms.
- Review of the association between x-ray irradiation, cancer, and ankylosing spondylitis.
Main Results:
- Rheumatic manifestations can be immunopathogenic features of neoplasm, direct consequences of tumors, or effects of cancer therapy.
- Conditions like Sjögren's syndrome, polymyositis, arthritis, and polymyalgia rheumatica can be linked to cancer.
- X-ray irradiation in ankylosing spondylitis patients is also associated with cancer.
Conclusions:
- Clinicians must be aware of the wide spectrum of rheumatic manifestations of malignancy.
- Early recognition of these associations can improve patient outcomes.
- Further research is needed to elucidate the complex relationship between cancer and rheumatic diseases.