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Synthesis and biological evaluation of proline derivatives as potential angiotensin converting enzyme inhibitor
G Giugliano1, P Grieco, A Ialenti
1Dipartimento di Chimica Farmaceutica e Tossicologica, Università degli Studi di Napoli.
Bollettino Della Societa Italiana Di Biologia Sperimentale
|January 1, 1996
Abstract:
The synthesis of a series of proline derivatives (1a-e and 2a-b) as pure isomers is described. These compounds were evaluated in vitro for their ability to inhibit angiotensin converting enzyme (ACE) and compared to the potency of captopril taken as a reference drug. They showed only a weak ACE inhibitory activity.