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Synthesis and pharmacological properties of 2,4-disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives. Part
R Jasztold-Howorko1, Z Machoń, M Wilimowski
1Department of Organic Chemistry, Medical Academy, Wrocław, Poland.
Polish Journal of Pharmacology
|September 1, 1995
Abstract:
2,4-Disubstituted 5-amino-6-pyrimidinecarboxylic acid derivatives 5-13 were synthesized and evaluated for their pharmacological activity. Compounds 5, 7, 9, 10 and 12 showed antiaggressive effect, compounds 6 and 10 showed synergism with hexobarbital while compound 6 exerted analgesic activity.