Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Standardized gentamicin dosing enhances peak serum concentrations

H Chase1, T W Austin, A M Bombassaro

  • 1Department of Medicine, Victoria Hospital, London, Ontario.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|February 1, 1996
PubMed
Summary

A standardized gentamicin dosing protocol significantly improved achieving target peak serum concentrations compared to empiric dosing. While not impacting clinical effectiveness or toxicity, this optimized dosing warrants further evaluation for gentamicin therapy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstracts of presentations to the Annual Meetings of the Canadian Association of General Surgeons Canadian Association of Thoracic Surgeons Canadian Hepato-Pancreato-Biliary Society Canadian Society of Surgical Oncology Canadian Society of Colon and Rectal Surgeons: Victoria, BC Sept. 10-13, 2009.

Canadian journal of surgery. Journal canadien de chirurgie·2022
Same author

Determinants of downloads and citations for articles published in Intensive Care Medicine.

Intensive care medicine·2019
Same author

Adherence to, and outcomes of, a galactomannan screening protocol in high-risk hematology patients.

Current oncology (Toronto, Ont.)·2018
Same author

Breast Cancer in the Bahamas in 2009-2011.

Breast cancer : basic and clinical research·2016
Same author

The truth about nutrition in the ICU.

Intensive care medicine·2013
Same author

Pseudomonas aeruginosa blepharitis in a patient with vancomycin induced neutropenia.

The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses·2012

Area of Science:

  • Pharmacology and Therapeutics
  • Infectious Diseases
  • Clinical Pharmacy

Background:

  • Empiric gentamicin dosing practices may lead to suboptimal serum concentrations.
  • Optimizing gentamicin dosing is crucial for maximizing efficacy and minimizing toxicity.

Purpose of the Study:

  • To evaluate a standardized gentamicin dosing protocol against empiric prescribing.
  • To assess improvements in clinical effectiveness, peak serum concentrations, and target attainment.
  • To monitor for gentamicin toxicity.

Main Methods:

  • A before-after program effectiveness evaluation was conducted in non-critically ill patients (16-65 years) with stable renal function.
  • A standardized intravenous gentamicin dose of 2 mg/kg every 12 hours was used in the intervention phase.

Related Experiment Videos

  • Clinical response, serum concentrations (peaks and troughs), and toxicity were monitored.

    • Main Results:

    • The standardized protocol achieved desired peak gentamicin concentrations in 97% of patients versus 59% in the control group (p < 0.001).
    • Mean peak serum concentrations were significantly higher with the standardized protocol (16.1 mumol/L vs. 11.2 mumol/L; p < 0.001).
    • No significant differences were observed in clinical effectiveness or the incidence of nephrotoxicity or ototoxicity.

    Conclusions:

    • A standardized gentamicin dosing protocol effectively increases the attainment of therapeutic peak serum concentrations.
    • The protocol did not significantly alter clinical effectiveness or toxicity profiles.
    • Further investigation into this standardized gentamicin dosing protocol is recommended.