Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[New muscle relaxants]

C Diefenbach1, W Buzello

  • 1Klinik für Anästhesiologie und Operative Intensivmedizin, Universität Köln.

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|February 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Attenuation of a rocuronium-induced neuromuscular block in patients receiving prednisolone.

Acta anaesthesiologica Scandinavica·2009
Same author

Influence of a continuous prednisolone medication on the time course of neuromuscular block of atracurium in patients with chronic inflammatory bowel disease.

British journal of anaesthesia·2008
Same author

Possible underestimation of histamine releasing potency of cisatracurium?

European journal of anaesthesiology·2005
Same author

Concept for postoperative analgesia after pedicled TRAM flaps: continuous wound instillation with 0.2% ropivacaine via multilumen catheters. A report of two cases.

British journal of plastic surgery·2003
Same author

[Application of muscle relaxants for rapid-sequence induction of anaesthesia].

Der Anaesthesist·2003
Same author

[The use of neuromuscular monitoring in Germany].

Der Anaesthesist·2003
Same journal

[Infection Prevention in the Intensive Care Unit: Evidence-Based Strategies for Reducing Healthcare-Associated Infections].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
Same journal

[Persistent Postoperative Opioid Use].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
Same journal

[Dexamethasone for Perioperative Analgesia].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
Same journal

[Treatment Expectations in the Perioperative Setting - Influence on Postoperative Pain Treatment].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
Same journal

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
Same journal

[Correction: Anaesthesiological Concepts in Paediatric Neurosurgery].

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS·2026
See all related articles

Mivacurium, rocuronium, and atracurium are neuromuscular blocking agents used for tracheal intubation. Their onset, duration, and side effects vary, with mivacurium and rocuronium offering rapid intubation but potential side effects, while cis-atracurium provides a favorable safety profile.

Area of Science:

  • Anesthesiology and Pharmacology

Background:

  • Nondepolarizing neuromuscular blocking agents are crucial for facilitating endotracheal intubation during general anesthesia.
  • Mivacurium, rocuronium, and atracurium represent distinct classes of these agents with varying pharmacokinetic and pharmacodynamic profiles.

Purpose of the Study:

  • To compare the clinical characteristics of mivacurium, rocuronium, and atracurium, focusing on their efficacy for tracheal intubation and associated side effect profiles.
  • To elucidate the pharmacokinetic and pharmacodynamic differences, including onset of action, duration of effect, and potential adverse events like histamine release and cardiovascular changes.

Main Methods:

  • Review of pharmacological data and clinical studies comparing mivacurium, rocuronium, and atracurium.
  • Analysis of key parameters: time to tracheal intubation, duration of action (e.g., DUR 25%), potency (ED95), and incidence of side effects such as histamine release and cardiovascular effects.

Related Experiment Videos

Main Results:

  • Mivacurium offers rapid intubation (2-3 min) but has a longer duration than succinylcholine and can cause histamine release and hypotension at higher doses. Its action is prolonged in patients with liver/renal disease or atypical cholinesterase.
  • Rocuronium provides rapid intubation (60-90 s) with no cumulative effects and minimal histamine release, though it has slight vagolytic effects. Elimination is primarily hepatic.
  • Cis-atracurium, an isomer of atracurium, is more potent and has a similar profile without significant histamine release or cardiovascular effects, and potentially less laudanosine release.

Conclusions:

  • Mivacurium, rocuronium, and cis-atracurium are effective neuromuscular blocking agents for tracheal intubation, each with distinct advantages and disadvantages.
  • Choice of agent depends on the clinical scenario, considering desired onset and duration, patient factors (e.g., liver/renal function), and potential for side effects like histamine release.