Lactose intolerance and osteoporosis in men

Area of Science:

• Bone Metabolism and Mineralization
• Gastroenterology and Nutrition

Background:

• Osteoporosis is a significant public health concern characterized by low bone mass and microarchitectural deterioration.
• Lactase deficiency, the inability to digest lactose, is common and can lead to reduced dairy consumption.

Observation:

• Three men with osteoporotic fractures presented with diagnosed lactase deficiency.
• These individuals exhibited low dietary calcium intake and reduced urinary calcium excretion.

Findings:

• Biochemical markers showed moderately elevated serum osteocalcin and parathyroid hormone levels.
• Histomorphometric analysis revealed increased osteoid parameters and bone resorption surfaces.
• The study suggests a potential link between lactase deficiency, low calcium intake, and osteoporosis development.

Implications:

• Dietary calcium restriction due to lactase deficiency may be a risk factor for osteoporosis.
• Further research is needed to clarify the relationship between lactase deficiency and bone health.
• Clinical awareness of this association could aid in osteoporosis prevention and management strategies.