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Recurrent psoriatic onychoperiostitis induced by hydroxychloroquine
J Sibilia1, B Cribier, R M Javier
1Rheumatology Department, Hautepierre Teaching Hospital, Strasbourg, France.
Revue Du Rhumatisme (English Ed.)
|December 1, 1995
Summary
Synthetic antimalarial drugs, like hydroxychloroquine, can worsen psoriasis. This case highlights psoriatic onychoperiostitis, a nail condition, in a patient with Sjögren
Area of Science:
- Dermatology
- Rheumatology
- Pharmacology
Background:
- Psoriatic skin lesions can be exacerbated by synthetic antimalarial drugs.
- Hydroxychloroquine is a common synthetic antimalarial agent.
- Primary Sjögren's syndrome is an autoimmune condition.
Observation:
- A patient with primary Sjögren's syndrome developed psoriatic onychoperiostitis.
- Psoriatic onychoperiostitis was precipitated by hydroxychloroquine therapy.
- The patient had pre-existing psoriatic skin lesions.
Findings:
- Hydroxychloroquine therapy can trigger psoriatic onychoperiostitis.
- Ungual abnormalities may be associated with primary Sjögren's syndrome.
- The exact incidence and causation of these nail abnormalities require further investigation.
Implications:
- Clinicians should be aware of potential dermatological side effects of hydroxychloroquine.
- Further research is needed to understand the link between Sjögren's syndrome, hydroxychloroquine, and nail pathology.
- This case underscores the importance of monitoring patients for skin and nail changes during antimalarial treatment.