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Related Experiment Videos

[Selenium, glutathione peroxidase, peroxides and platelet functions]

D Vitoux1, P Chappuis, J Arnaud

  • 1Laboratoire central de biochimie, hôpital Lariboisière, Paris, France.

Annales De Biologie Clinique
|January 1, 1996
PubMed
Summary

Selenium protects against vascular disorders by modulating platelet aggregation and synthesis of inflammatory compounds. Selenium supplementation benefits individuals with low selenium levels, reducing risks of thrombosis and coronary heart disease.

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[Interlaboratory comparison/external quality assessment].

Annales de biologie clinique·2013

Area of Science:

  • Biochemistry
  • Cardiovascular Science
  • Nutritional Science

Context:

  • Renewed interest in selenium's protective role in vascular disorders.
  • Low selenium levels linked to increased risk of coronary disease and atherosclerosis.
  • Selenium modulates leukotriene and prostaglandin synthesis in endothelial cells and platelets.

Purpose:

  • Investigate the protective role of selenium in vascular health.
  • Examine the relationship between selenium levels, platelet function, and cardiovascular risk.
  • Evaluate the impact of selenium supplementation on platelet aggregation and eicosanoid synthesis.

Summary:

  • Selenium, as part of glutathione peroxidase, reduces peroxides, regulating eicosanoid production and balancing pro- and anti-aggregatory states.

Related Experiment Videos

  • Platelets have high, selenium-sensitive glutathione peroxidase activity; deficiency increases aggregation and thromboxane B2/leukotriene synthesis.
  • Selenium administration in deficient subjects enhances glutathione peroxidase, inhibiting platelet hyperaggregation and leukotriene synthesis.

    • Impact:

    • Supports selenium supplementation for preventing thrombosis and coronary heart disease in deficient populations.
    • Highlights selenium's critical role in regulating platelet function and inflammatory pathways.
    • Suggests potential public health benefits of addressing selenium deficiency in regions like France.