Visual deprivation at the critical period modulates photic evoked responses

Average visual evoked responses (AVER) were recorded from the striate cortex of normal (control) and monocular visually deprived Long-Evans hooded rats. One month of monocular visual deprivation (MD) at the critical period of development resulted in marked reduction of all the three AVER components (i.e., components P2, N2 and P3) as compared to the control recording (P < 0.001). In control animals, the AVER amplitudes of the two hemispheres were identical, while in MD rats, the P2 and N2 components of the AVER obtained from the hemisphere ipsilateral to the MD eye were markedly smaller than those of the AVER obtained from the contralateral hemisphere (P < 0.001). The latencies of the late components (N2 and P3) obtained from the hemisphere ipsilateral to the MD eyes were significantly delayed as compared to those from the contralateral hemisphere (P < 0.05 for N2, P < 0.01 for P3). The AVER following paired photic stimuli with various time intervals between the stimuli were used to study the neuronal recovery function of control animals compared to MD animals. The AVER to the second stimulus obtained from the MD rats exhibited greater attenuation in their amplitude responses than the AVER obtained from the control group, i.e., slower neuronal recovery. The neurophysiological changes observed in this study may relate to the neurocytological alteration occurring in the striate cortex following monocular visual deprivation at the critical period. In conclusion, AVER recorded from monocular visually deprived rats during the critical period is a simple and reliable electrophysiological animal model to study neuroplasticity during postnatal development.