Physiological effects of ovarian hormones: clinical aspects and compliance

Area of Science:

• Reproductive endocrinology and women's health.

Background:

• Menopause is defined by the cessation of menstruation, leading to ovarian hormone deprivation.
• This hormonal change results in diverse physiological effects, impacting women's health significantly.
• Common symptoms like irregular periods and hot flashes prompt consideration of hormone replacement therapy (HRT).

Purpose of the Study:

• To highlight the importance of hormone replacement therapy (HRT) for managing menopausal symptoms.
• To underscore the role of HRT in preventing osteoporosis and cardiovascular disease in post-menopausal women.
• To emphasize the need for improved patient and physician awareness regarding HRT risks and benefits to enhance compliance.

Main Methods:

• Review of existing literature on menopause and hormone replacement therapy.
• Analysis of reasons for HRT use, including symptom management and disease prevention.
• Examination of factors contributing to low compliance with HRT regimens.

Main Results:

• Menstrual disturbances and hot flashes are primary indications for HRT.
• Prevention of osteoporosis and cardiovascular disease are significant secondary benefits of HRT.
• Low compliance with HRT is often due to continued bleeding and concerns about side effects.

Conclusions:

• Effective management of menopausal symptoms and prevention of long-term health issues necessitate informed HRT decisions.
• Enhanced awareness of HRT's risks and benefits is essential for improving treatment adherence among post-menopausal women.
• Physician-patient communication is key to optimizing the use of hormone therapy in menopause management.