Effect of isolation on morphine-induced running and changes in body temperature

1. The influence of isolation of three durations 8, 15 and 30 days has been examined in mice on the effects of morphine on rectal temperature and on locomotor activity. Isolated mice were compared to non isolated mice with the same age. 2. Morphine (20 mg/kg ip) induced in mice an early hypothermia followed by a late hyperthermia. The hypothermic effect was significantly reduced following isolation, but the duration of isolation (8, 15, 30 days) had no influence. Isolation did not modify the hyperthermic effect of morphine. 3. Morphine (40 mg/kg ip) induced in mice an increase in locomotor activity called "running". The running activity was significantly increased following isolation. The duration of isolation (8, 15, 30 days) did not seem to influence this effect. 4. These results show that isolation does not modify in the same way every effects of morphine, they suggest that isolation alters the mechanism involved in the running activity and in the hypothermic effect. The nature of these mechanisms is discussed.