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[Sclerosing peritonitis and practolol (author's transl)]

T Hess, P Stucki

    Medizinische Klinik
    |July 15, 1977
    PubMed
    Summary

    Practolol, a beta blocker, was linked to sclerosing peritonitis, a rare condition causing abdominal scarring. This drug was withdrawn from the market in 1975 due to severe side effects.

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    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Ophthalmology

    Background:

    • Beta-adrenergic blockers, like Practolol, were used for cardiovascular conditions.
    • Practolol was associated with various systemic side effects, including skin and eye complications.
    • Sclerosing peritonitis is a rare condition characterized by abdominal inflammation and fibrosis.

    Observation:

    • A case of sclerosing peritonitis was observed in a patient with a history of Practolol therapy.
    • The observed case shared similarities with idiopathic fibroplastic peritonitis described previously.
    • The patient exhibited other known side effects of Practolol, such as skin manifestations and eye complications.

    Findings:

    • There is strong evidence suggesting a causal relationship between long-term Practolol treatment and the development of sclerosing peritonitis.
    • Practolol-induced side effects can be severe and multi-systemic.
    • Sclerosing peritonitis, though rare, is a significant potential adverse effect of Practolol.

    Implications:

    • Practolol was withdrawn from the market in 1975 due to its adverse effects.
    • This case highlights the importance of recognizing drug-induced conditions.
    • Understanding drug-related toxicities is crucial for patient safety and clinical practice.

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