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Related Experiment Videos

Apoptosis in the aged dog brain

W Kiatipattanasakul1, S Nakamura, M M Hossain

  • 1Department of Veterinary Pathology, Faculty of Agriculture, University of Tokyo, Japan.

Acta Neuropathologica
|September 1, 1996
PubMed
Summary

Aged dogs exhibit brain cell apoptosis, a process similar to Alzheimer's disease. This cell death correlates with dementia, suggesting dogs may serve as a valuable model for studying human Alzheimer's disease.

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Area of Science:

  • Neuroscience
  • Comparative Pathology
  • Gerontology

Background:

  • Alzheimer's disease (AD) is a neurodegenerative disorder characterized by neuronal loss and cognitive decline.
  • Apoptosis, or programmed cell death, is implicated in AD pathogenesis.
  • Aged canines share certain physiological and pathological similarities with aging humans.

Purpose of the Study:

  • To investigate the presence and characteristics of apoptosis in the brains of aged dogs.
  • To correlate brain cell apoptosis with cognitive decline (dementia index) and aging.
  • To evaluate the potential of aged dogs as a model for human Alzheimer's disease.

Main Methods:

  • Utilized the TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) method to detect in situ DNA fragmentation.

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  • Morphologically examined brain tissue from aged dogs.
  • Quantified ApopTag-positive cells and correlated findings with age and dementia index.

    • Main Results:

    • Apoptosis was observed in both neurons and glial cells (astrocytes, oligodendrocytes) in aged dog brains.
    • The number of apoptotic cells slightly increased with age but did not correlate with senile plaques.
    • A significant correlation was found between the number of apoptotic cells and the dementia index.

    Conclusions:

    • Brain cell apoptosis contributes to dementia in aged dogs.
    • Aged dogs represent a potential animal model for studying Alzheimer's disease due to shared apoptotic mechanisms.
    • Further research in canine models could provide insights into human AD.