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Related Experiment Videos

Experimental induction of epithelial-mesenchymal interconversions

M Guarino1, F Giordano

  • 1Department of Anatomical Pathology, Hospital of Vimercate, Italy.

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie
|November 1, 1995
PubMed
Summary

Cells can switch between epithelial and mesenchymal states, a process observed in development and disease. This experimental cell phenotype conversion may reflect inherent cellular plasticity and activation of silent genetic programs.

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cancer Biology

Background:

  • Epithelial-to-mesenchymal transition (EMT) and its reverse (MET) are crucial cellular processes.
  • These transitions involve significant changes in cell morphology, biochemistry, and function.
  • Experimental induction can lead to partial or complete phenotype modulation, sometimes irreversibly.

Purpose of the Study:

  • To investigate the conditions and implications of experimental cell phenotype interconversion.
  • To explore the reversibility and stability of epithelial and mesenchymal phenotype shifts.
  • To understand if experimental conversions recapitulate in vivo physiological and pathological processes.

Main Methods:

  • In vitro cell culture under specific conditions (e.g., collagen, growth factors, DNA methylation agents).

Related Experiment Videos

  • Experimental manipulation to induce mesenchymal-to-epithelial conversion (MEC).
  • Observation and analysis of cell phenotype changes, including morphology, biochemistry, and function.

    • Main Results:

    • Epithelial cells can undergo a shift to a mesenchymal phenotype (EMT) and vice versa (MEC) under specific in vitro conditions.
    • The observed conversions can be fully reversible or stable and irreversible.
    • Complete abrogation of parent cell characteristics can occur, indicating a profound phenotype switch.

    Conclusions:

    • Experimentally induced cell phenotype conversions suggest an inherent cellular potential for differentiation.
    • These conversions may activate normally silent genetic programs for epithelial or mesenchymal differentiation.
    • The findings provide insights into phenomena observed in embryonic development, tissue repair, and cancer progression.