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Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
Published on: February 25, 2011
Extraribosomal functions of ribosomal proteins
1Department of Biochemistry and Molecular Biology, The University of Chicago, IL 60637, USA.
Trends in Biochemical Sciences
|May 1, 1996
Abstract:
The discovery of DNA-binding motifs in ribosomal proteins has led to the conjecture that the transition of the ribosome from an RNA to an RNP machine occurred by adding pre-existing proteins. Supportive, but circumstantial, evidence for the hypothesis is adduced from the finding that many ribosomal proteins have a second function apart from the particle. These extraribosomal functions are enumerated.
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