Related Experiment Video
Updated: Jul 17, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Review article: drug-induced pancreatitis
1Department of Veterans Affairs Medical Center, University of Texas Southwestern Medical Center, Dallas, TX 75216, USA.
Drug-induced pancreatitis is uncommon but should be considered in adults when other causes are absent. Definitive diagnosis involves drug cessation and potential re-administration, though this is often ethically challenging.
Area of Science:
- Gastroenterology
- Clinical Pharmacology
Background:
- Drug-induced pancreatitis is an uncommon but serious condition.
- A diverse range of medications have been implicated.
- The condition is typically acute and can range in severity.
Purpose of the Study:
- To highlight the importance of considering drug-induced pancreatitis.
- To outline diagnostic criteria for drug-induced pancreatitis.
- To emphasize challenges in diagnosis and information accessibility.
Main Methods:
- Review of existing literature and case reports.
- Discussion of diagnostic criteria, including temporal association and response to drug withdrawal.
- Consideration of ethical limitations in drug rechallenge.
Main Results:
- Drug-induced pancreatitis is a rare cause of the condition in adults.
- Establishing definitive proof can be difficult due to ethical constraints on rechallenge.
- Information on drug-related pancreatitis may be limited, especially for new drugs.
Conclusions:
- Clinicians must consider drug-induced pancreatitis when evaluating patients.
- Diagnostic certainty is often based on circumstantial evidence due to rechallenge limitations.
- Consulting regulatory agencies and manufacturers is recommended for comprehensive information.
More Related Videos
07:10Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
Published on: April 1, 2022
07:38Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
Published on: May 10, 2024
Related Concept Videos
Acute Pancreatitis I: Introduction
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Chronic Pancreatitis I: Introduction
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Acute Pancreatitis I: Introduction
Acute Pancreatitis II: Pathophysiology
Chronic Pancreatitis I: Introduction
Chronic Pancreatitis II: Pathophysiology