Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Cytokines and allergic rhinitis

¹Children's Hospital of Pittsburgh, Pa 15213-2583, USA.

Allergy and Asthma Proceedings

|July 1, 1996

Summary

Cytokine profiles in allergic rhinitis differ based on treatment. Corticosteroids decrease interleukin-4 (IL-4), while immunotherapy increases interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), indicating distinct therapeutic mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pharmacokinetics and tolerability of a new intravenous immunoglobulin preparation, IGIV-C, 10% (Gamunex, 10%).

Vox sanguinis·2003

Same author

Effect of experimental influenza A infection on systemic immune and inflammatory parameters in allergic and nonallergic adult subjects.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2002

Same author

Urinary histamine metabolite elevations during experimental influenza infection.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001

Same author

Long-term safety and efficacy of a chlorofluorocarbon-free beclomethasone dipropionate extrafine aerosol.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001

Same author

Combination of inhaled corticosteroids plus other medications in the management of moderate to severe persistent asthma.

Allergy and asthma proceedings·2000

Same author

Abnormal middle ear pressures during experimental influenza A virus infection--role of Eustachian tube function.

Auris, nasus, larynx·2000

Area of Science:

Immunology
Allergology
Respiratory Medicine

Background:

Cytokines play a crucial role in the pathophysiology of allergic diseases.
Specific cytokines like IL-4, IL-1, IL-2, IL-6, GM-CSF, and TNF-alpha are implicated in allergic rhinitis.
These cytokines have been detected in nasal tissues and secretions of patients with allergic rhinitis.

Purpose of the Study:

To summarize the role of cytokines in allergic diseases.
To investigate the changes in cytokine expression associated with corticosteroid therapy and immunotherapy in allergic rhinitis.
To elucidate the distinct mechanisms of action for different therapeutic interventions based on cytokine modulation.

Main Methods:

Analysis of cytokine expression in nasal biopsies and/or secretions from patients with allergic rhinitis.
Comparison of cytokine profiles before and after treatment with corticosteroids or immunotherapy.
Review and summarization of existing literature on cytokine involvement in allergic diseases (as referenced in Table II).

Main Results:

Corticosteroid therapy was associated with a decrease in interleukin-4 (IL-4) expression.
Immunotherapy was associated with an increase in interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) expression.
Differences in cytokine expression were observed between patients receiving corticosteroids and those undergoing immunotherapy.

Conclusions:

Corticosteroid therapy and immunotherapy exert their therapeutic effects through different mechanisms.
The modulation of specific cytokines (IL-4, IL-2, IFN-gamma) underlies the distinct actions of these treatments in allergic rhinitis.
Understanding these cytokine-mediated pathways can inform future therapeutic strategies for allergic diseases.

Related Experiment Videos