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Monoclonal antibody affinities of structurally related modified nucleosides
D Higginson-Clarke1, R Guevara García, C Rodríguez Tanty
1Molecular Biology Department, National Center for Scientific Research, Havana, Cuba.
Molecular and Chemical Neuropathology
|May 1, 1996
Abstract:
A scale of relative affinities of a series of 2'-deoxycytidine and cytidine (CD) derivatives was established based on the data of cross-reactivities of these compounds as well as the displacements obtained from a competitive ELISA. No correlation could be established between the nucleosides modifying structures and the affinities. This can be explained by the possibilities of the modifying structures of intra- and intermolecular nonimmunospecific interactions owing to their degree of functionalization.