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Immunohistochemical analysis of c-Fos and c-Jun in retinoblastoma
F Faraldi1, A Calzolari, M Forni
1Istituto di Clinica Oculistica, Università degli Studi di Firenze, Italy.
Acta Geneticae Medicae Et Gemellologiae
|January 1, 1996
Abstract:
The c-fos promoter is negatively regulated by the retinoblastoma (Rb)-susceptibility-gene-encoded protein as well as by other genes involved in the control of transcription, cell cycle regulation and neoplastic transformation. We have examined by immunohistochemistry the c-Fos and c-Jun proteins in five cases of retinoblastoma in order to evaluate eventual alterations in their expression in vivo, possibly related to a gene mutation or to loss of Rb negative control.