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Polyactive as a bone-filler in a beagle dog model
G J Meijer1, A van Dooren, M L Gaillard
1Department of Oral-Maxillofacial Surgery, Prosthodontics and Special Dental Care, Faculty of Medicine, University of Utrecht, The Netherlands.
Summary
Precalcifying PEO/PBT 80/20 copolymer implants enhances bone bonding. Underfilling defects also promotes calcification and bone ingrowth for better bone filler integration.
Area of Science:
- Biomaterials Science
- Orthopedic Research
- Tissue Engineering
Background:
- Calcification is key for bone-bonding with polyetheretherketone/polybutylene terephthalate (PEO/PBT) hydrogel copolymers.
- Polyactive is a new generation of bone fillers utilizing these copolymers.
Purpose of the Study:
- To investigate if precalcification of PEO/PBT 80/20 copolymer implants improves bone bonding rates.
- To assess the impact of implant swelling and defect filling strategy on bone ingrowth.
Main Methods:
- A beagle dog study compared precalcified and non-precalcified PEO/PBT 80/20 implants in bone cavities.
- Control groups included hydroxyapatite granules with PEO/PBT 70/30 and unfilled defects.
- Implant pore size changes and mineralized component presence were analyzed.
Main Results:
- Precalcified PEO/PBT 80/20 implants showed significantly higher mineralized component compared to controls.
- Implant swelling reduced pore size, hindering optimal bone ingrowth.
- Underfilling defects allowed for implant expansion, promoting bone ingrowth.
Conclusions:
- Precalcification of PEO/PBT 80/20 copolymers enhances the bone bonding rate.
- Strategic underfilling of bone defects is crucial for optimal calcification and bone ingrowth with these copolymers.